This malaria parasite of humans is has a micx of P. vivax and P. malariae traits. The cellular components resemble that if P. malariae but it is found in immature Red Blood Cells like P. vivax. It is most simal to P. vivax except for the fact that it is resistant to people who are negative for the Duffy blood group. For this reason it is more common then P. vivax in sub-Saharan Africa.
Microgametocyctes and Macrogametocytes are injested by the mosquito from the human host.
The gametocytes fertilize and form a zygote.
An Oocyst forms in the gut of the mosquito and contains sporozoites.
The Oocyst ruptures and the sporozoties are released.
When the mosquito takes a second blood meal from another human host the sporozoites are injected into the new host.
The sporozoites are injected into the host and enter the liver.
They then for a schizont which matures and then ruptures releasing merozoites.
The merooites then form a ring trophozoite.
This trophozoite can then form gametocytes or go into the erythrocytic cycle.
The ring trophozoites form mature trophozoites.
these then form a schizont and then a mature shizont.
The mature shizont ruptures releaseing merozoites.
These form ring trophozoites which then can form gametocytes.
The exo-erythrocytic cycle is 8 days and the erythrocytic cycle is 48 hours.
The merozoites total 12-24 in the immature Red Blood Cell.
Shizonts are see in the blood.
Gametocytes are often round or ovoid.
People with this disease will often relapse soon after the inital infection because the parasite will remain in the liver.