Trypanosoma equiperdum is a species of trypanosome that infects horses and other animals in the family equidae. Trypanosoma equiperdum differs from other trypanosome species in that the parasite is venerally transmitted. It can also be transmitted from mother to foal. The parasite is found in the genital organs of infected animals and causes Dourine, or covering sickness. Donkeys show no symptoms, but are still a carrier of the parasite.
Trypanosoma equiperdum causes Dourine in equine animals. Dourine infection is characterized by swelling of the genitalia, cutaneous plaques, and neurological signs. Swelling may extend up to the abdomen. Neurological signs include restlessness and weight shifting from one leg to the other, weakness, incoordination, and eventually paralysis. Affected animals may become emaciated. The symptoms vary with the virulence of the strain and the nutritional status of the animal. Mortality rates for Dourine infection are very high.